Bioavailability of butorphanol after intranasal administration to horses
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چکیده
منابع مشابه
Bioavailability and pharmacokinetics of lorazepam after intranasal, intravenous, and intramuscular administration.
The purpose of this study was to evaluate the pharmacokinetic profile of intranasal lorazepam in comparison to currently established administration routes. Eleven healthy volunteers completed this randomized crossover study. On three occasions, each separated by a 1-week washout, subjects received a 2 mg dose of lorazepam via the intranasal, intravenous, or intramuscular route. Blood samples we...
متن کاملComparative Pharmacokinetics and Bioavailability of Ceftiofur in Horses After Intravenous, Intramuscular, and Subcutaneous Administration
Ceftiofur sodium administered as a single dose (2.2 mg/kg, IV and SC) resulted in plasma concentrations of active drug similar to those achieved with the approved IM route. By varying dosing intervals after appropriate concentrations are achieved by IV, SC or IM administration should be effective for treatment of bacterial infections caused by susceptible organisms. Therefore, dosage intervals ...
متن کاملIntranasal administration of butorphanol benefits old patients undergoing H-uvulopalatopharyngoplasty: a randomized trial
BACKGROUND To evaluate intranasal administration of butorphanol on postoperative pain and early postoperative cognitive dysfunction in old patients undergoing H-uvulopalatopharyngoplasty (H-UPPP). METHODS A total of 260 male patients (65 to 77 years old) with obstructive sleep apnea hypopnea syndrome and scheduled for H-UPPP were divided randomly to receive intranasal butorphanol, intravenous...
متن کاملOral bioavailability of ATP after prolonged administration.
Purinergic receptors are important for the regulation of inflammation, muscle contraction, neurotransmission and nociception. Extracellular ATP and its metabolites are the main ligands for these receptors. Occasional reports on beneficial results of ATP administration in human and animal studies have suggested the bioavailability of oral ATP supplements. We investigated whether prolonged daily ...
متن کاملIntranasal administration of drugs.
OBJECTIVE To investigate how nasally applied substances distribute in the nose depending on the form of application. DESIGN Observer-blinded study. SETTING University hospital research unit. PARTICIPANTS Fifteen healthy volunteers aged 22 to 32 years. INTERVENTIONS Forms of application included (1) nasal drops applied with a pipette, (2) nasal spray, and (3) a system producing squirts. ...
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ژورنال
عنوان ژورنال: BULGARIAN JOURNAL OF VETERINARY MEDICINE
سال: 2020
ISSN: 1313-3543,1311-1477
DOI: 10.15547/bjvm.2019-0051